By Bhushan, Vikas

ISBN-10: 1405104090

ISBN-13: 9781405104098

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Biochem. J. 8 2 , 401. , Ellis, R. , and Bromer, W, (1968). Science 161, 3837. Crowfoot, D . M . (1935). Nature {London) 136, 591. D e Zoeten, L. , and D e Bruin, O. A. (1961). Ree. Trav. Chim. Pays. Bas 8 0 , 907. Dodson, E . , Harding, M . , Hodgkin, D . C , and Rossmann, Μ . G. (1966). /. Mol. Biol. 16, 227. Fredericq, E . (1954). / . Polym. Sei. 12, 287. Fredericq, E. (1957). / . Amer. Chem. Soc. 79, 599. Harding, M . , Hodgkin, D . C , Kennedy, A. , and Weitzman, P. D . (1966). / . Mol. Biol.

B l u n d e l l : N o , I do not. M y contention was that insulin was stored in the rat and probably other mammals as a zinc insulin hexamer. This is consistent with the evidence that zinc occurs in the j8-granules of most species except the guinea pig and coypu. Zinc is important in storage. T h e physiological concentrations in the blood are so low that the hexamer will certainly dissociate—the dimer probably would as well. E . B . A s t w o o d : Would zinc be necessary for the conformation of the monomer?

J. 221 (in press). Low, B . , and Einstein, J. R. (1960). Nature {London) 186, 470. Marcker, K. (1960). Acta Chem. Scand. 14, 2071. Markus, G. (1964). / . Biol. Chem. 239, 4163. , and Rossi, C. A. (1968). Bio­ chem. J. 108, 247. Mercóla, D . (1969). P h . D . Dissertation, University of California, Los Angeles, Cali­ fornia. Mercóla, D . , Morris, J. W. , and Arquilla, Ε. R. (1967). Biochim, Biophys. Acta 133, 224. 34 τ. L. BLUNDELL ET AL. Morris, J. W. , Mercóla, D . , and Arquilla, Ε . R. (1968).

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Anatomy by Bhushan, Vikas


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